2-(Ethylamino)ethanol → HCID 136186582, compound

HRID 1936675Notes

Reaction equation

HRID 1936675 reaction equation
CS([C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1)(=O)=O.[CH2:26]([NH:28][CH2:29][CH2:30][OH:31])[CH3:27]>ClCCl>[CH2:26]([N:28]([C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1)[CH2:29][CH2:30][OH:31])[CH3:27]

Participants

4

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 1356707527-Methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 136186582HCID 136186582, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner to Example 31 reaction of 7-methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.40 g) and 2-(ethylamino)ethanol (0.64 g) in dichloromethane (12 ml) yielded the title compound, 137 mg, m.p. 141-2° C. (recrystallized from isopropanol-ether).

Workup

  1. customyielded
  2. customthe title compound, 137 mg, m.p. 141-2° C. (recrystallized from isopropanol-ether)

Sources & evidence

ORD record
ord-ead93a3374df4576ad530ca638607a18
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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