Acetic Acid → HCID 135670782, compound

HRID 1936686Notes

Reaction equation

HRID 1936686 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1.C[O-].[Na+].[C:27](O)(=[O:29])C>CO>[CH3:27][O:29][C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 10942334Sodium MethoxideHCID 135670760HCID 135670760, compound

Product 1

HCID 135670782HCID 135670782, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred mixture of 5,6-dihydro-3-methylthio-5-oxo-7-(2-propoxyphenyl)pyrimido[5,4-e][1,2,4]triazine (0.80 g) and sodium methoxide (prepared from sodium, 0.28 g and methanol) in methanol (50 ml) was heated under reflux for 1.5 hours. The cooled reaction mixture was neutralized by the addition of glacial acetic acid (0.7 ml) to afford a yellow precipitate (0.63 g) which was recrystallized from methanol to afford the title compound, 0.47 g, m.p. 221-222° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. customThe cooled reaction mixture

Sources & evidence

ORD record
ord-799a2341990a43e0881881ee93f32265
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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