Ammonia → HCID 135670753, compound

HRID 1936687Notes

Reaction equation

HRID 1936687 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1.[NH3:24]>>[NH2:24][C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 135670800HCID 135670800, compound

Product 1

HCID 135670753HCID 135670753, compound

Procedure

In a similar manner to that described in Example 87, 3-methylthio-8-oxo-6-(2-propoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine (1.42 g) was reacted with ethanolic ammonia (70 ml) for 20 hours to give the crude title compound, (0.80 g) which together with another sample (0.17 g), similarly prepared, was recrystallized from ethanol to afford the title compound, 0.54 g, m.p. 255-256° C.

Workup

  1. customto give the crude title compound, (0.80 g) which together with another sample (0.17 g)
  2. customsimilarly prepared
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-627654fd780945d8a0c791dbeb20565d
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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