HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1936702Generated: October 27, 2026
Ammonia → 3-Amino-4-cyanopyridine-2-carboxamide
https://huagongshe.com/reaction/1936702
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 3-amino-4-cyanopyridine-2-carboxylate | HCID 22462344 | — |
| Product | 3-Amino-4-cyanopyridine-2-carboxamide | HCID 22462404 | 94% |
Reaction Steps
A mixture of liquid ammonia (30 ml) and ethyl 3-amino-4-cyanopyridine-2-carboxylate (Preparation 11; 2.8 g, 0.0147 mol) was heated at 100° C. in an autoclave for 18 hours. The ammonia was allowed to evaporate and the resulting product crystallized from ethyl acetate to give the title compound as an off-white solid (2.2 g, 94%), m.p. >310° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06391885B1 |
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| Source dataset | uspto-grants-2002_05 |
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| ORD ID | ord-9d794489500f47a3bfcbd5d51740e5f8 |
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| Source note | uspto-grants-2002_05 |
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