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HRID1936753

反应详情

EQUATION

反应方程式

HRID 1936753 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc2c(cnn2Cc2ccccc2)c1
HCID212069

1H-Indazol-5-amine, 1-benzyl-

C14H13N3

结构：Clc1ncnc2ccc(I)cc12
HCID11173809

4-Chloro-6-iodoquinazoline

C8H4ClIN2

PRODUCTS

生成物

1
结构：Cl.Ic1ccc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2c1
HCID21952130

未命名化合物

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

4-Chloro-6-iodoquinazoline (5.8 g) was treated with 5-amino-1-benzy-1H-indazole (3.90 g) in acetonitrile (500 ml) at reflux under N2 for 18 hours (Procedure A). Subsequent cooling and filtration gave the title compound (8.26 g); m/z (M+1)+478.

WORKUP

后处理

  1. temperatureat reflux under N2 for 18 hours (Procedure A)
  2. temperatureSubsequent cooling
  3. filtrationfiltration