Triphenylphosphine → HCID 54088438, compound

Participants

Reaction Steps

(1-Benzyl-1H-indazol-5-yl)-(6-iodoquinazolin-4-yl)-amine (0.48 g) in DMF under CO was treated with sodium formate (0.1 g) and catalytic quantities of triphenyl phosphine and bistriphenylphosphine palladium (II) chloride at 110° C. The mixture was cooled, added to 5% sodium hydroxide and extracted with ethyl acetate. The aqueous phase was treated with 2N HCl and the precipitated solid filtered and dried to give the title compound (0.07 g); δH [2H6]DMSO 13.35(1H,bs), 10.40(1H,s), 9.30(1H,s), 8.60(1H,s), 8.30(1H,d), 8.17(2H,d), 7.84(1H,d), 7.72(1H,s), 7.30(5H,m,), 5.70(2H,s); m/z (M+1)+396.

Provenance & Evidence