HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannanecarbonitrile, tributyl- → HCID 22609748, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannanecarbonitrile, tributyl- | HCID 200512 | — |
| Reactant | (1-Benzyl-1H-indazol-5-yl)-(6-iodoquinazolin-4-yl)-amine | HCID 21952131 | — |
| Catalyst | (Butane-1,4-diyl)bis(diphenylphosphane)--dichloropalladium (1/1) | HCID 10974057 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 22609748 | HCID 22609748 | 44.3% |
Reaction Steps
(1-Benzyl-1H-indazol-5-yl)-(6-iodoquinazolin-4-yl)-amine (3.58 g) in dioxane (30 ml) under N2 was treated with tributyltin cyanide (2.51 g) and catalytic quantities of 1.4-bis-(diphenylphosphino)-butane palladium (II) chloride and tetrakis (triphenylphosphine) palladium at reflux for 5 days. The mixture was absorbed onto silica and chromatographed to give the title compound (1.25 g); δH [2H6]DMSO 10.20(1H,s), 9.15(1H,s), 8.65(1H,s), 8.24(1H,s), 8.18(2H,m), 7.89(1H,s), 7.70(2H,m), 7.30(5H,m), 5.70(2H,s); m/z (M+1)+377.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391874B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-129b52f4d14a4a82b774c7b13fe22d98 |
| Source note | uspto-grants-2002_05 |