1-(2,3-difluorobenzyl)-1H-indazol-5-amine → (1-(2,3-Difluorobenzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-yl)-amine hydrochloride

HRID 1936794Notes

Reaction equation

HRID 1936794 reaction equation
[F:1][C:2]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[CH:7]=[N:6]1.[Cl:20][C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([C:31]3[O:32][C:33]([CH3:36])=[N:34][N:35]=3)[CH:29]=2)[N:24]=[CH:23][N:22]=1>>[ClH:20].[F:1][C:2]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH:14][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([C:31]5[O:32][C:33]([CH3:36])=[N:34][N:35]=5)[CH:29]=4)[N:24]=[CH:23][N:22]=3)=[CH:11][CH:12]=2)[CH:7]=[N:6]1

Participants

3

Reactant 2

HCID 219520591-(2,3-difluorobenzyl)-1H-indazol-5-amineHCID 226097254-Chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609822(1-(2,3-Difluorobenzyl)-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-yl)-amine hydrochloride

Procedure

The title compound was prepared according to Procedure A from 1-(2,3-difluorobenzyl)-1H-indazol-5-ylamine and 4-chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.90(1H,s), 9.47(1H,s), 8.91(1H,s), 8.60(1H,d), 8.25(1H,s), 8.15(2H,m), 7.89(1H,d), 7.72(1H,dd), 7.40(1H,m), 7.18(1H,m), 6.98(1H,m), 5.83(2H,s), 2.67(3H,s); m/z (M+1+) 470.

Sources & evidence

ORD record
ord-73dded616f2b4080a45033de80d0f688
Source dataset
uspto-grants-2002_05
Patent number
US06391874B1

Reaction notes

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