3-Chloro-4-(3-fluorobenzyloxy)aniline → HCID 22609800, compound

HRID 1936796Notes

Reaction equation

HRID 1936796 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1)[NH2:5].Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([C:29]3[O:30][C:31]([CH3:34])=[N:32][N:33]=3)[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([C:29]4[O:30][C:31]([CH3:34])=[N:32][N:33]=4)[CH:27]=3)[N:22]=[CH:21][N:20]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1

Participants

3

Reactant 2

HCID 70592633-Chloro-4-(3-fluorobenzyloxy)anilineHCID 226097254-Chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609800HCID 22609800, compound

Procedure

The title compound was prepared according to Procedure A from 3-chloro-4-(3-fluoro-benzyloxy)aniline and 4-chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.73(1H,bs), 9.38(1H,s), 8.94(1H,s), 8.57(1H,d), 8.10(1H,d), 7.90(1H,d), 7.65(1H,dd), 7.45(1H,m), 7.30(3H,m), 7.16(1H,m), 5.30(2H,s), 2.65(3H,s); m/z (M+1+) 462.

Sources & evidence

ORD record
ord-fbc2fc23bbad43e88ec9aac5660ea8f5
Source dataset
uspto-grants-2002_05
Patent number
US06391874B1

Reaction notes

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