4-(2-Fluoro-benzyloxy)-phenylamine → (4-(2-Fluoro-benzyloxy)-phenyl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine hydrochloride

HRID 1936798Notes

Reaction equation

HRID 1936798 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][O:5][C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[CH:8][CH:7]=1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]3[O:29][C:30]([CH3:33])=[N:31][N:32]=3)[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:17].[F:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][O:5][C:6]1[CH:12]=[CH:11][C:9]([NH:10][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[O:29][C:30]([CH3:33])=[N:31][N:32]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 176080564-(2-Fluoro-benzyloxy)-phenylamineHCID 226097254-Chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)quinazoline

Product 1

HCID 22609860(4-(2-Fluoro-benzyloxy)-phenyl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazolin-4-yl)-amine hydrochloride

Procedure

The title compound was prepared according to Procedure A from 4-(2-fluoro-benzyloxy)aniline and 4-chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl)-quinazoline; δH [2H6]DMSO 11.72(1H,bs), 9.41(1H,s), 8.91(1H,s), 8.59(1H,d), 8.10(1H, d), 7.65(3H,m), 7.45(1H,m), 7.25(2H,m), 7.18(2H,d), 5.20(2H,s), 2.65(3H,s); m/z (M+1+) 428.

Sources & evidence

ORD record
ord-299c8511bf8547dcbe736c443e5c7c6a
Source dataset
uspto-grants-2002_05
Patent number
US06391874B1

Reaction notes

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