Bromine → HCID 18388324, compound

HRID 1936858Notes

Reaction equation

HRID 1936858 reaction equation
[O:1]=[C:2]1[C:10]2[C:6](=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:8][C:9]=2[S:11][CH2:12][CH2:13][CH3:14])[CH2:5][CH2:4][CH2:3]1.[Br:20]Br>C(Cl)(Cl)Cl>[Br:20][CH:3]1[CH2:4][CH2:5][C:6]2=[C:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:8][C:9]([S:11][CH2:12][CH2:13][CH3:14])=[C:10]2[C:2]1=[O:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 2778813Ethyl 4-oxo-3-(propylsulfanyl)-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxylate

Product 1

HCID 18388324HCID 18388324, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Ethyl 4,5,6,7-tetrahydro-4-oxo-3-propylthiobenzo[c]thiophene-1-carboxylate (25.29 g) was dissolved in chloroform (380 ml); a solution of bromine (13.81 g) in chloroform (20 ml) was added dropwise at room temperature over a period of 20 minutes. After the reaction mixture was stirred at room temperature for 40 minutes, it was washed with a 2% aqueous solution of sodium sulfite (400 ml), water, a saturated aqueous solution of sodium hydrogen carbonate and water in that order, and dried (MgSO4), after which the solvent was distilled off to yield ethyl 5-bromo-4,5,6,7-tetrahydro-4-oxo-3-propylthiobenzo[c]thiophene-1-carboxylate (29.07 g, 90.9%), which was then recrystallized from ethyl acetate-hexane. Light-yellow prisms. Melting point 93-94° C.

Workup

  1. washit was washed with a 2% aqueous solution of sodium sulfite (400 ml), water
  2. dry with materiala saturated aqueous solution of sodium hydrogen carbonate and water in that order, and dried (MgSO4)
  3. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-6fb8093017ac4da3b7f81b50facd42f3
Source dataset
uspto-grants-2002_05
Patent number
US06391905B1

Reaction notes

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