Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1936898Generated: October 27, 2026

(S)-methyl 2-hydroxy-3-phenylpropanoate → (2R)-2-[4'-(2-Benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-phenyl-propionic acid

https://huagongshe.com/reaction/1936898

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-methyl 2-hydroxy-3-phenylpropanoateHCID 5289077—
Reactant4'-(2-Benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-olHCID 10721373—
Product(2R)-2-[4'-(2-Benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-phenyl-propionic acidHCID 9810271—

Reaction Steps

The title compound was prepared from 4′-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 87-89° C.; MS m/e 696 (M+);

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06391897B2
Source datasetuspto-grants-2002_05
ORD IDord-7055df3fa3e9419583b91697f820c93b
Source noteuspto-grants-2002_05