Lawesson's reagent → HCID 22462447, compound

HRID 1936981Notes

Reaction equation

HRID 1936981 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH:8]3[CH2:17][CH2:16][CH2:15][CH:9]3[C:10](=O)[NH:11][C:12]=2[CH:13]=1)([O-:3])=[O:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:27])=CC=1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH:8]3[CH2:17][CH2:16][CH2:15][CH:9]3[C:10](=[S:27])[NH:11][C:12]=2[CH:13]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 22462497HCID 22462497, compound

Product 1

HCID 22462447HCID 22462447, compound

Procedure

7-Nitro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (91 mg, 0.30 mmol) is stirred with Lawesson's reagent (170 mg, 0.43 mmol) for 6 hours at room temperature. The batch is concentrated by evaporation in a vacuum, and the residue is purified on silica gel with toluene: 52 mg (54%) of product.

Workup

  1. concentrationThe batch is concentrated by evaporation in a vacuum
  2. customthe residue is purified on silica gel with toluene

Sources & evidence

ORD record
ord-db38168889324698a12611caab81abb4
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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