Ammonia → HCID 22462429, compound

HRID 1936982Notes

Reaction equation

HRID 1936982 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH:8]3[CH2:17][CH2:16][CH2:15][CH:9]3[C:10](=S)[NH:11][C:12]=2[CH:13]=1)([O-:3])=[O:2].[NH3:18]>>[NH2:18][C:10]1[CH:9]2[CH2:15][CH2:16][CH2:17][CH:8]2[C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:12]=2[N:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462447HCID 22462447, compound

Product 1

HCID 22462429HCID 22462429, compound

Procedure

7-Nitro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (47 mg, 0.19 mmol) is stirred in 7N methanolic ammonia (10 ml) for 15 hours at room temperature. The batch is concentrated by evaporation in a vacuum. The residue is purified on silica gel with dichloromethane-2-propanol/methanol: 21 mg (48%) of product.

Workup

  1. concentrationThe batch is concentrated by evaporation in a vacuum
  2. customThe residue is purified on silica gel with dichloromethane-2-propanol/methanol

Sources & evidence

ORD record
ord-64177fe055f74d61813cb6e0bc6f7ef4
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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