反应详情

65% Nitric acid (0.33 ml) is mixed at 0° C. with 96% sulfuric acid (0.44 ml). To this end, a solution of 1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (1.9 g, 5.3 mmol) in dichloromethane (5 ml) is added in drops. After 1 hour at room temperature, the batch is poured onto ice water, the solid is filtered off and washed with water. Column-chromatographic purification (SiO2) of the filter residue with ethyl acetate-hexane yields 0.65 g (53%) of product.

1. additionthe batch is poured onto ice water
2. filtrationthe solid is filtered off
3. washwashed with water
4. customColumn-chromatographic purification (SiO2) of the filter residue with ethyl acetate-hexane