Ammonia → HCID 22462461, compound

HRID 1936999Notes

Reaction equation

HRID 1936999 reaction equation
[Cl:1][C:2]1[C:11]2[NH:10][C:9](=S)[CH:8]3[CH2:13][CH2:14][CH2:15][CH:7]3[C:6]=2[CH:5]=[C:4]([Cl:16])[CH:3]=1.[NH3:17]>>[NH2:17][C:9]1[CH:8]2[CH2:13][CH2:14][CH2:15][CH:7]2[C:6]2[CH:5]=[C:4]([Cl:16])[CH:3]=[C:2]([Cl:1])[C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462471HCID 22462471, compound

Product 1

HCID 22462461HCID 22462461, compoundYield 74%

Procedure

Analogously to Example 4, 6,8-dichloro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (100 mg, 0.37 mmol) is reacted with 7N methanolic ammonia solution (20 ml) to form 70 mg (74%) of product.

Sources & evidence

ORD record
ord-27f7fa2970e544509f5931750d3d68d6
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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