Ammonia → HCID 22462478, compound

HRID 1937003Notes

Reaction equation

HRID 1937003 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8](=S)[CH:7]3[CH2:14][CH2:15][CH2:16][CH:6]3[C:5]=2[CH:4]=1.[NH3:19]>>[NH2:19][C:8]1[CH:7]2[CH2:14][CH2:15][CH2:16][CH:6]2[C:5]2[CH:4]=[C:3]([C:2]([F:18])([F:17])[F:1])[CH:12]=[CH:11][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462456HCID 22462456, compound

Product 1

HCID 22462478HCID 22462478, compoundYield 76%

Procedure

Analogously to Example 4, 8-(trifluoromethyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (93 mg, 0.34 mmol) in 7N methanolic ammonia solution (20 ml) is reacted to form 66 mg (76%) of product.

Sources & evidence

ORD record
ord-234fa31d9d6d438392a78670fb202943
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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