Lawesson's reagent → HCID 22462440, compound

HRID 1937009Notes

Reaction equation

HRID 1937009 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=O)[CH:6]3[CH2:13][CH2:14][CH2:15][CH:5]3[C:4]=2[CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:25])=CC=1>>[F:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[S:25])[CH:6]3[CH2:13][CH2:14][CH2:15][CH:5]3[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 22462501HCID 22462501, compound

Product 1

HCID 22462440HCID 22462440, compoundYield 80%

Procedure

Analogously to Example 4, 8-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (280 mg, 1.36 mmol) is reacted with Lawesson's reagent (608 mg, 1.5 mmol) to form 240 mg (80%) of product.

Sources & evidence

ORD record
ord-8c5252abe70347c193f06d66577ec42a
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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