Ammonia → HCID 22462502, compound

HRID 1937010Notes

Reaction equation

HRID 1937010 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=S)[CH:6]3[CH2:13][CH2:14][CH2:15][CH:5]3[C:4]=2[CH:3]=1.[NH3:16]>>[NH2:16][C:7]1[CH:6]2[CH2:13][CH2:14][CH2:15][CH:5]2[C:4]2[CH:3]=[C:2]([F:1])[CH:11]=[CH:10][C:9]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462440HCID 22462440, compound

Product 1

HCID 22462502HCID 22462502, compoundYield 95%

Procedure

Analogously to Example 4, 8-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (240 mg, 1.08 mmol) in 7N methanolic ammonia solution (30 ml) is reacted to form 210 mg (95%) of product.

Sources & evidence

ORD record
ord-c57816ea79ec4da4b28bf2b393fe3513
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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