Ammonia → HCID 22462473, compound

HRID 1937012Notes

Reaction equation

HRID 1937012 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:6]3[CH2:15][CH2:14][CH2:13][CH:7]3[C:8](=S)[NH:9][C:10]=2[CH:11]=1.[NH3:16]>>[NH2:16][C:8]1[CH:7]2[CH2:13][CH2:14][CH2:15][CH:6]2[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:11][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462457HCID 22462457, compound

Product 1

HCID 22462473HCID 22462473, compoundYield 99%

Procedure

Analogously to Example 4, 7-Fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (170 mg, 0.77 mmol) in 7N methanolic ammonia solution (20 ml) is reacted to form 160 mg (99%) of product.

Sources & evidence

ORD record
ord-e977ccca4ff04f008ff48494280d95a2
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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