HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → HCID 22462436, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | HCID 18516404 | HCID 18516404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22462436 | HCID 22462436 | 94.1% |
Reaction Steps
A solution of 6-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (100 mg, 0.48 mmol) and Lawesson's reagent (512 mg, 1.26 mmol) in THF (20 ml) is refluxed for 1.5 hours and concentrated by evaporation. Column chromatography of the residue with ethyl acetate-hexane yields 100 mg (93%) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391887B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-65c0063f96f242ca9e5f164488aa06b2 |
| Source note | uspto-grants-2002_05 |