Ammonia → HCID 22462485, compound

HRID 1937015Notes

Reaction equation

HRID 1937015 reaction equation
[F:1][C:2]1[C:11]2[NH:10][C:9](=S)[CH:8]3[CH2:13][CH2:14][CH2:15][CH:7]3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH3:16]>>[NH2:16][C:9]1[CH:8]2[CH2:13][CH2:14][CH2:15][CH:7]2[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([F:1])[C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462436HCID 22462436, compound

Product 1

HCID 22462485HCID 22462485, compoundYield 64%

Procedure

Analogously to Example 4, 6-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (100 mg, 0.45 mmol) in 7N methanolic ammonia solution (15 ml) is reacted to form 59 mg (64%) of product.

Sources & evidence

ORD record
ord-57c7d9a9eb3b4409a0e91b27ee668f94
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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