Ammonia → HCID 22462491, compound

HRID 1937019Notes

Reaction equation

HRID 1937019 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]2[CH:10]3[CH2:19][CH2:18][CH2:17][CH:11]3[C:12](=S)[NH:13][C:14]=2[CH:15]=1.[NH3:20]>>[NH2:20][C:12]1[CH:11]2[CH2:17][CH2:18][CH2:19][CH:10]2[C:9]2[CH:8]=[CH:7][C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)=[CH:15][C:14]=2[N:13]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22462496HCID 22462496, compound

Product 1

HCID 22462491HCID 22462491, compoundYield 82%

Procedure

Analogously to Example 4, 7-(2-furanyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione (95 mg, 0.35 mmol) in 7N methanolic ammonia solution (30 ml) is reacted to form 72 mg (82%) of product.

Sources & evidence

ORD record
ord-c843da21cd2141808a38a628016d2ec5
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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