Lawesson's reagent → HCID 22462430, compound

HRID 1937022Notes

Reaction equation

HRID 1937022 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[CH:11]4[CH2:20][CH2:19][CH2:18][CH:12]4[C:13](=O)[NH:14][C:15]=3[CH:16]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:30])=CC=1>>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[CH:11]4[CH2:20][CH2:19][CH2:18][CH:12]4[C:13](=[S:30])[NH:14][C:15]=3[CH:16]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 22462492HCID 22462492, compound

Product 1

HCID 22462430HCID 22462430, compoundYield 84.3%

Procedure

Analogously to Example 4, 7-(4-morpholinyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (100 mg, 0.37 mmol) is reacted with Lawesson's reagent (164 mg, 0.41 mmol) to form 90 mg (84%) of product.

Sources & evidence

ORD record
ord-fad0154c51844087a288cbdcd1be2017
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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