Lawesson's reagent → HCID 86758086, compound

HRID 1937026Notes

Reaction equation

HRID 1937026 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]2[CH:11]3[CH2:20][CH2:19][CH2:18][CH:12]3[C:13](=O)[NH:14][C:15]=2[CH:16]=1)=[O:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:30])=CC=1>>[CH3:1][O:2][C:3]([CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]2[CH:11]3[CH2:20][CH2:19][CH2:18][CH:12]3[C:13](=[S:30])[NH:14][C:15]=2[CH:16]=1)=[O:4]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 18516355HCID 18516355, compound

Product 1

HCID 86758086HCID 86758086, compoundYield 117.8%

Procedure

Analogously to Example 4, 7-(methoxycarbonylethyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (120 mg, 0.44 mmol) is reacted with Lawesson's reagent (195 mg, 0.48 mmol) to form 150 mg of product.

Sources & evidence

ORD record
ord-170e52d1a1924a649905c8e699010e68
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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