HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopropionitrile → n-(2-Cyanoethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopropionitrile | HCID 1647 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Product | n-(2-Cyanoethyl)benzamide | HCID 284729 | — |
Reaction Steps
Benzoyl chloride and aminoethylcyanide are reacted to give N-benzoyl-aminoethylcyanide, which is reacted with hydrogen sulfide in ammonia to yield the thioamide, which is reacted with an appropriate a-halo ketone to yield the desired thiazole. Treatment with 5N hydrochloric acid removes the protecting benzoyl group to wive the desired amine product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06392049B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-c9c40cf26e254306899b24a35900fa4f |
| Source note | uspto-grants-2002_05 |