p-Toluenesulfonic acid → HCID 18388460, compound

Participants

Reaction Conditions

Reaction Steps

To a 500 mL three-necked flask equipped with a mechanical stirrer, 40 g of 4-tert-butylphenol, 40 g of hexanes and 1.9 g of p-toluenesulfonic acid are charged. The slurry is heated to 60° C. at which time 62 g of 1,1-diphenylethylene is added. The temperature is increased to 110° C. and the hexanes are removed by distillation. After 4.5 hours, the reaction mass is cooled to ambient temperature and purified by silica gel chromatography using heptane/ethyl acetate as the eluent. Sixty (60) grams of the title compound is obtained whose structure is confirmed by 1H nmr.

Provenance & Evidence