Lithium amide → HCID 18388473, compound

HRID 1937064Notes

Reaction equation

HRID 1937064 reaction equation
[Cl:1][C:2]1[CH:37]=[CH:36][C:5]2=[N:6][N:7]([C:9]3[CH:10]=[C:11]([CH:18]=[C:19]([C:22]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH3:23])[C:20]=3[OH:21])[CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[N:8]=[C:4]2[CH:3]=1.[NH2-].[Li+]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:37]=[CH:36][C:5]2=[N:6][N:7]([C:9]3[CH:10]=[C:11]([CH:18]=[C:19]([C:22]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH3:23])[C:20]=3[OH:21])[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH2:11][CH2:10][CH2:9][CH2:20][CH2:19][CH2:22][CH3:23])=[O:15])[N:8]=[C:4]2[CH:3]=1

Participants

4

Reactant 2

HCID 24532Lithium amideHCID 18388471HCID 18388471, compound

Product 1

HCID 18388473HCID 18388473, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound prepared in Example 26 is refluxed in toluene in the presence of lithium amide and EXXAL® 8 (mixture of octanols, Exxon-Mobil) for four hours. The title compound is obtained.

Sources & evidence

ORD record
ord-41f684dbda2945b9bcfda2a2d8b13098
Source dataset
uspto-grants-2002_05
Patent number
US06392056B1

Reaction notes

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