Water → 2-(2,6-Dichloro-4-trifluoromethylphenylhydrazino)succinonitrile

Participants

Reaction Steps

2-(2, 6-Dichloro-4-trifluoromethylphenylhydrazono)succinonitrile (0.296 g, 1 mmol), sodium cyanide (0.196 g, 4 equivalents), water (1 ml) and acetic acid (5 ml) were added successively to a sealed tube. After reacting for 40 hours at 20° C. the mixture was added to saturated sodium bicarbonate solution, extracted (dichloromethane), washed (water), dried (magnesium sulphate) and evaporated to give a mixture which contained 40% of the desired title compound, NMR 3.1 (m,2H), 4.5(m,1H), 5.89(m, 1H), 6.94(d,1H), 7.71(s,2H), together with 60% of unchanged starting hydrazone.

Provenance & Evidence