3-(2,6-Dichloro-4-trifluoromethylphenylhydrazino)propionitrile → 3-{2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazinylidene}propanenitrile
Reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][NH:14][CH2:15][CH2:16][C:17]#[N:18]>ClC1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:9])[F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[CH:15][CH2:16][C:17]#[N:18]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 65 °C
Procedure
Cupric chloride (0.673 g, 2.5 equivalents) was added in one portion to a solution of 3-(2,6-dichloro-4-trifluoromethylphenylhydrazino)propionitrile (0591 g, 2 mmol) in chlorobenzene, and the mixture heated at 65° C. for 50 minutes. The reaction was judged to be complete and was cooled, washed (water), dried (magnesium sulphate), evaporated and separated by chromatography on silica gel to give 3-(2,6-dichloro-4-trifluoromethylphenylhydrazono)propionitrile,
Workup
- temperaturewas cooled
- washwashed (water)
- dry with materialdried (magnesium sulphate)
- customevaporated
- customseparated by chromatography on silica gel
Sources & evidence
- ORD record
- ord-948b83752b024e799885ec1d1a418dae
- Source dataset
- uspto-grants-2002_05
- Patent number
- US06392081B1
Reaction notes
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