Hydrochloric Acid → 4-(Aminomethyl)benzonitrile hydrochloride

Participants

Reaction Steps

By use of a reactor similar to that employed in Example 3, concentrated hydrochloric acid (33.4 g) was added dropwise to a mixture containing crude p-cyanobenzylamine (41.3 g) obtained in Preparation Example 1 and water (25.8 g). The resultant mixture was cooled to room temperature, thereby forming white solid. The solid was separated through filtration at room temperature; washed twice with water (10 g×2); and dried under vacuum, thereby yielding 35.2 g of p-cyanobenzylamine hydrochloride (yield as reduced to p-cyanobenzylamine: 70%). Through analysis of the thus-obtained p-cyanobenzylamine hydrochloride, the p-cyanobenzylamine content and the p-xylylenediamine content were found to be 77 mass % and 0.6 mass %, respectively; and the hydrogen chloride content was found to be 22 mass %. The water content was found to be 0.3 mass %, and the bulk density was calculated to be 0.5 g/ml.

Provenance & Evidence