HCID 10583570, compound → HCID 10726681, compound

HRID 1937111Notes

Reaction equation

HRID 1937111 reaction equation
[O:1]1[C@H]2[C@@H]1C(=O)[C@H]1[C@@H]2[C@@H]1C(OCC)=O.[F:14][C:15]1[C:16](=[O:26])[C@H:17]2[C@@H:19]([CH:20]=1)[C@@H:18]2[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[F:14][C:15]1[C:16](=[O:26])[C@H:17]2[C@@H:19]([CH:20]=1)[C@@H:18]2[C:21]([O:23][CH2:24][CH2:25][OH:1])=[O:22]

Participants

3

Reactant 2

HCID 10583570HCID 10583570, compoundHCID 10773828HCID 10773828, compound

Product 1

HCID 10726681HCID 10726681, compoundYield 152.1%

Procedure

In addition, in the same manner as described above, from 5.45 g of ethyl (1S, 3R, 4R, 5R, 6S)-3,4-epoxy-2-oxobicyclo[3.1.0]hexane-6-carboxylate, 1.01 g of ethyl (1S, 5R, 6S)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxyl ate, and 1.67 g of 2-hydroxyethyl (1S, 5R, 6S)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylate were obtained.

Sources & evidence

ORD record
ord-156cf4d03a6f443fa700890faaf3bf76
Source dataset
uspto-grants-2002_05
Patent number
US06392086B1

Reaction notes

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