Water → HCID 9793894, compound

In a 300 mL beaker was placed 5.78 g (57 mmol) of 3-morpholinone (I), 50% (w/w)sodium hydroxide (5.02 g, 63 mmol), 100 mL of water and a magnetic stir bar. The resulting solution was heated for 30 min at a gentle boil then cooled to room temperature. While the solution was stirring at room temperature, the glycolonitrile (40 percent aqueous, 8.13 g, 57 mmol) was added dropwise. The solution was stirred at room temperature for 1 h. at which time a 13C NMR indicated that the reaction was complete. 13C NMR (D2O): δ50.3, 53.4, 119.4, 179.7, 180.9 ppm.

1. temperatureThe resulting solution was heated for 30 min at a gentle boil
2. stirringThe solution was stirred at room temperature for 1 h. at which time a 13C NMR

ORD record

ord-f0fb4682a9164864861d5d073da0b2a6

Source dataset

uspto-grants-2002_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06392095B2