HCID 69957985, compound → HCID 69957560, compound

HRID 1937134Notes

Reaction equation

HRID 1937134 reaction equation
[O:1]1[C@H:9]2[C@@H:10]3[C@@H:14]([C@@H:2]1[C:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C:8]=12)[C@@H:13]([CH3:15])[O:12][C:11]3=[O:16]>C(O)C.[C].[Pd]>[O:1]1[C@H:9]2[C@@H:10]3[C@@H:14]([C@@H:2]1[C@H:3]1[C@@H:8]2[CH2:7][CH2:6][CH2:5][CH2:4]1)[C@@H:13]([CH3:15])[O:12][C:11]3=[O:16]

Participants

4

Reactant 1

HCID 69957985HCID 69957985, compound

Product 1

HCID 69957560HCID 69957560, compoundYield 61.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Similarly to Example 2, 0.22 g(10% by weight) of 10% palladium-carbon were added to 2.20 g(9.99 mmol) of (3R,3aR,4R,9S,9aS)-4,9-epoxy-3-methyl-3a,4,5,6,7,8,9,9a-octahydronaphtho[2,3-c]furan-1(3H)-one in 5 ml of ethanol solution and catalytic reduction was conducted at ambient temperature under 98.1 Kpa to obtain 1.36 g of (3R,3aR,4S,4aR,8aS,9R,9aS)-4,9-epoxy-3-methyl-decahydronaphtho[2,3-c]furan-1(3H)-one(yield 61%).

Workup

  1. customwas conducted at ambient temperature under 98.1 Kpa

Sources & evidence

ORD record
ord-198445bd0fc840679c05a88f9d6af3de
Source dataset
uspto-grants-2002_05
Patent number
US06392059B1

Reaction notes

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