Hydrogen Peroxide → HCID 69956726, compound

Participants

Reaction Steps

Similarly to Example 8, after 663.7 mg(2.81 mmol) of (1R,3R,3aR,4aR,8aS,9aR)-1-methoxy-3-methyl-4-methylene-dodecahydronaphtho[2,3-c]furan were reacted with 4.21 ml (1.5 equivalents) of borane-tetrahydrofuran complex(1M), it was oxidized by adding 3.00 ml of 30% hydrogen peroxide solution and 3.00 ml of 10% aqueous solution of sodium hydroxide to obtain 538.2 mg of (1R,3R,3aS,4S,4aR,8aS,9aR)-4-hydroxymethyl-1-methoxy-3-methyl-dodecahydronaphtho[2,3-c]furan(yield 75%) and 55.2 mg of (1R,3R,3aS,4R,4aR,8aS,9aR)-4-hydroxymethyl-1-methoxy-3-methyl-dodecahydronaphtho[2,3-c]furan(8%). (1R,3R,3aS,4S,4aR,8aS,9aR)-4-hydoxymethyl-1-methoxy-3-methyl-dodecahydronaphtho[2,3-c]furan

Provenance & Evidence