HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 69691131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(4-Methoxyphenyl)benzothiophene | HCID 4137391 | — |
| Reactant | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69691131 | HCID 69691131 | 59% |
Reaction Steps
By essentially following the procedure detailed in Example 1, Part D, but using thionyl chloride in refluxing dichloromethane to form the benzoyl choride, the title compound was prepared from 2-(4-methoxyphenyl)-benzo[b]thiophene and 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride in 59% yield as an oil following radial chromatography (SiO2; gradient of 2-5% MeOH in CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391901B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-b6a3dc2cc5244d6bb90be8ce106252ef |
| Source note | uspto-grants-2002_05 |