HCID 22462795, compound → HCID 22462732, compound

Participants

Reaction Steps

By essentially following the conditions of Example 2, Part A, the title compound was prepared from 1-benzyloxy-carbonyl-2-oxo-4-hydroxymethylimidazolidine (Saijo et al. Chem. Pharm. Bull. 1980, 28, 1459) and 6-benzyloxy-3-[3-methyl-4-[(1-pyrrolidinyl)methyl]benzyl]-2-(4-hydroxyphenyl)benzo[b]thiophene (Example 8, Part C) in 28% yield following radial chromatography (SiO2; 20% then 25% then 40% THF with 5% TEA in hexanes).

Provenance & Evidence