Methanol → HCID 22462732, compound

Participants

Reaction Steps

By essentially following the conditions detailed in Example 8, Part F, the free base of the title compound was prepared as a solid from 6-benzyloxy-3-[3-methyl-4-[(1-pyrrolidinyl)methyl]benzyl]-2-[4-(3-benzyloxycarbonyl-2-oxo-imidazolidin-4-ylmethoxy)phenyl]benzo[b]thiophene (Part A) in 42% yield following radial chromatography (SiO2; 1% then 3% then 5% MeOH in CHCl3 sat'd with NH4OH). The product was converted to the oxalate salt according to the conditions described in Example 1; Part G.

Provenance & Evidence