Trifluoroacetic acid → HCID 22462762, compound

Participants

Reaction Steps

By essentially following the conditions described in Example 1, Part F, the free base of the title compound was prepared as a foam from 2-(4-aminophenyl)-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (Example 16; Part D) and 3-carboxycyclopentanone in 98% yield following radial chromatography (SiO2; 1% then 2% then 5% MeOH in CHCl3 sat'd with NH4OH). The solid was taken up in 5 mL of MeOH and was treated with 1.2 eq of CF3CO2H. The solution was concentrated in vacuo to give the title compound.

Provenance & Evidence