HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 69691236, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Oxo-1,3-thiazolidine-4-carboxylic acid | HCID 65272 | — |
| Reactant | HCID 178478890 | HCID 178478890 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 69691236 | HCID 69691236 | 67% |
Reaction Steps
By essentially following the conditions described in Example l, Part F, the free base of the title compound was prepared as a foam from 2-(4-aminophenyl)-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (Example 16; Part D) and (−)-2-oxo-4-thiazolidinecarboxylic acid in 67% yield following radial chromatography (SiO2; 1% then 2% then 4% MeOH in CHCl3 sat'd with NH4OH). The product was converted to the oxalate salt according to the proceedure described in Example 1, Part G.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391901B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-7ee6735a75244ee482c610085ddcb713 |
| Source note | uspto-grants-2002_05 |