Methyl Isocyanate → HCID 22462773, compound

Participants

Reaction Steps

6-Hydroxy-3-[3-methoxy-4-[(1-pyrrolidinyl)methyl]benzyl]-2-[4-aminophenyl]benzo[b]thiophene (80 mg) was dissolved in THF (5.0 mL), treated with sodium bicarbonate (45 mg) while stirring at ambient temperature, cooled to 0° C. in an ice bath before treated with methyl isocyanate (42 μL) under argon. The reaction mixture. was stirred at ambient temperature for 24 h and concentrated. Chromatography with Et3N:MeOH:EtOAc (5:10:85) afforded the title compound (50 mg).

Provenance & Evidence