Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 1-acetyloxy-3-carboxyadamantane | HCID 2818210 | — |
| Reactant | 3-(Cycloundecen-1-yl)-1,2-diazacycloundec-2-ene | HCID 53630274 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22463573 | HCID 22463573 | 70% |
Reaction Steps
In an atmosphere of nitrogen, 10 mmole of 1-acetyloxy-3-carboxyadamantane obtained by the above method was dissolved in 10 ml of DMF. To the mixture, 15 mmole of N,N′-carbodiimidazol in the form of powder was added in one portion. After stirring for 1 hour at the room temperature, 15 mmole of dimethylamine and 15 mmole of diazabicycloundecene were added. The mixture was heated to 100° C. and stirred for 8 hours. As a result, the conversion of 1-acetyloxy-3-carboxyadamantane was 80%, and 1-acetyloxy-3-(N,N-dimethylcarbamoyl)adamantane (yield 70%) was formed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06392104B1 |
|---|
| Source dataset | uspto-grants-2002_05 |
|---|
| ORD ID | ord-813fb82744264e6cb95130afa6518fe4 |
|---|
| Source note | uspto-grants-2002_05 |
|---|
