Acetic Acid → 3,5-Dihydroxyadamantane-1-carboxylic acid

Participants

Reaction Steps

A reactor was charged with 10 mmole of 1,3-adamantanediol, 1 mmole of NHPI, 0.005 mmole of Co(AA)2 and 25 mL of acetic acid, then equipped with a gas bag of mixed gas (a mixed gas of 2 L of carbon monoxide and 0. 5 L of oxygen; pressure: 5 kg/cm ). The resultant mixture was stirred for 6 hours at 60° C. to give 1-carboxy-3,5-adamantanediol (yield 80%). The conversion of 1,3-adamantanediol was 99%.

Provenance & Evidence