Hydrochloric Acid → HCID 178479670, compound

Participants

Reaction Steps

To a solution of 1-(6-chloronaphth-2-ylsulphonyl)-4-[(2-tert-butyloxypyrimidin-4-yl)benzoyl]piperazine (120 mg, 0.213 mmol) in dichloromethane (5 ml) was added a solution of hydrogen chloride in methanol (0.24 ml of ˜4.5 M, 1.06 mmol). A precipitate formed immediately, and the reaction was stirred at ambient temperature for 1 hr. The solvent was removed in vacuo and the residue triturated with methanol. The solid was collected by filtration to give 1-(6-chloronaphth-2-ylsulphonyl)-4-[(2-hydroxypyrimidin-4-yl)benzoyl]piperazine hydrochloride as a colourless solid.

Provenance & Evidence