1-(4-Fluorophenyl)-3-(4-benzyloxyphenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole → 1-(4-Fluorophenyl)-3-(4-hydroxyphenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole

Participants

Reaction Steps

Compound 8 (from Example B) (1 mmol.) is dissolved in EtOH (25 mL) and 10% Pd/C (25 mg) is added. The reaction mixture is stirred under an atmosphere of H2 and monitored by tlc. When the reaction is complete, the solution is filtered and evaporated to afford a residue which, after purification by HPLC, affords title compound 9.

Provenance & Evidence