HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodophenol → 1-(4-Fluorophenyl)-3-(4-iodophenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodophenol | HCID 10894 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | 1-(4-Fluorophenyl)-4-hydroxymethyl-5-methyl-2-(4-methylsulfonylphenyl)pyrrole | HCID 10546382 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Fluorophenyl)-3-(4-iodophenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole | HCID 22460679 | — |
Reaction Steps
Compound 6 (from Example A) (1 mmol) is added to a solution of diethylazodicarboxylate (1 mmol), triphenylphosphine (1 mmol) and 4-iodophenol (1 mmol) in dry THF (25 mL). The progress of the reaction is monitored by tlc. When the reaction is complete, water is added and the crude product is extracted in ethyl acetate. The extract is dried and evaporated and the title compound 25 is purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395724B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-6d9cd3565f084a96b6b308e00ec90878 |
| Source note | uspto-grants-2002_05 |