HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (+)-trans-1-(3,4-Dichlorobenzamido)-2-hydroxy-7-nitrotetraline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoyl chloride, 3,4-dichloro- | HCID 76403 | — |
| Reactant | (+)-trans-1-Amino-2-hydroxy-7-nitrotetraline | HCID 21338530 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (+)-trans-1-(3,4-Dichlorobenzamido)-2-hydroxy-7-nitrotetraline | HCID 21338528 | 103.3% |
Reaction Steps
A solution of 112 (2.1 g) in warm THF (300 mL) was treated with triethylamine (5 mL) and the solution allowed to come to room temperature. A solution of 3,4-dichlorobenzoyl chloride (2.3 g) in THF (50 mL) was added dropwise over 20 min. After stirring over night, the solvent was evaporated to give a solid (3.97 g) that had the appropriate nmr spectrum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395735B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-102accdd4c434bc1a1a09fe58fb623ef |
| Source note | uspto-grants-2002_05 |