5-Aminoindole → (1H-Indol-5-yl)pyrido[3,4-d]pyrimidin-4-yl-amine

HRID 1937391Notes

Reaction equation

HRID 1937391 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.Cl[C:12]1[C:13]2[CH:21]=[CH:20][N:19]=[CH:18][C:14]=2[N:15]=[CH:16][N:17]=1>>[NH:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:12]3[C:13]4[CH:21]=[CH:20][N:19]=[CH:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 122716344-Chloropyrido(3,4-d)pyrimidine

Product 1

HCID 22460818(1H-Indol-5-yl)pyrido[3,4-d]pyrimidin-4-yl-amineYield 15%

Procedure

This product was prepared in 15% yield from 5-aminoindole (1.1 eq.) and 4-chloropyrido[3,4-d]pyrimidine (1 eq.). MP 265° C.; LC-MS: 262 (MH+).

Sources & evidence

ORD record
ord-f7253e6816d54eccbe32b7c399e9b41a
Source dataset
uspto-grants-2002_05
Patent number
US06395733B1

Reaction notes

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