Benzenamine, 3-ethynyl- → HCID 18473281, compound

HRID 1937395Notes

Reaction equation

HRID 1937395 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][N:8]([CH2:11][CH2:12][O:13][CH3:14])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:15][C:16]1[CH:17]=[C:18]([C:22]#[CH:23])[CH:19]=[CH:20][CH:21]=1>CO>[C:22]([C:18]1[CH:17]=[C:16]([NH:15][C:2]2[C:3]3[CH:10]=[CH:9][N:8]([CH2:11][CH2:12][O:13][CH3:14])[C:4]=3[N:5]=[CH:6][N:7]=2)[CH:21]=[CH:20][CH:19]=1)#[CH:23]

Participants

4

Reactant 2

HCID 104682Benzenamine, 3-ethynyl-HCID 154008504-Chloro-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 18473281HCID 18473281, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47, this product was prepared in 81% yield from 4-chloro-7-(2-methoxy-ethyl)-7H-pyrrolo[2,3-d]pyrimidine (1.0 eq) and m-aminophenyl acetylene (1.2 eq) in methanol. M.P. 240-241° C.; LC-MS: 292(MH+); RP18-HPLC RT: 4.16 min.

Sources & evidence

ORD record
ord-ae4bbcbb8a97433e92e687f1b0e0ca8b
Source dataset
uspto-grants-2002_05
Patent number
US06395733B1

Reaction notes

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