Benzenamine, 3-ethynyl- → HCID 22460850, compound

Participants

Reaction Steps

This material was prepared from 4-chloro-6-methyl-pyrido[3,4-d]pyrimidine (1.0 eq.) and 3-ethynylaniline (1.1 eq.) as described for Example 74. After extraction chromatography of the residue on silica in 20% to 80% acetone/hexanes afforded 166 mg of the title product as its free-base which was converted to the title product (M.P. 250-252° C.; LC-MS: 261 (MH+); anal.RP-HPLC: 3.69 min.).

Provenance & Evidence